Zollinger ellison zes syndrome is characterized by gastric acid hypersecretion resulting in severe acidrelated peptic disease and diarrhea. Zollingerellison syndrome zes is an endocrinopathy characterized by gastrinsecreting tumors, responsible for causing the formation of multiple, refractory, and recurrent peptic ulcers in the distal duodenum and proximal jejunum. Type ii lesions are caused by gastrinomas gastrinproducing tumors, also known as zollinger ellison syndrome. Zes may occur sporadically or as part of an autosomal dominant familial syndrome called multiple endocrin.
Experts do not know the exact cause of zollingerellison syndrome. Surgical treatment of zollingerellison syndrome request pdf. See management and prognosis of the zollinger ellison syndrome gastrinoma. In most cases, the patient has multiple endocrine neoplasia type i men1 and should be investigated with serum sequencing for men1 gene 16 the frequency of type ii gnets is around 7% and the lesions are usually small and multiple. Pode ser esporadico ou associado a sindrome da neoplasia endocrina multipla tipo 1. Zollingerellison syndrome zes is an endocrinopathy characterized by. Zollingerellison syndrome zes is caused by a nonbeta islet cell, gastrinsecreting tumor of the pancreas that stimulates the acidsecreting cells of the stomach to maximal activity, with consequent gastrointestinal mucosal ulceration. We use cookies to offer you a better experience, personalize content, tailor advertising, provide social media features, and better understand the use of our services. Zollingerellison syndrome is a rare disorder that occurs when one or more tumors form in the pancreas and duodenum. The role of gastrin in causing the hyperplasia is discussed since in the zollinger ellison syndrome it is formed ectopically in very large amounts. Value of surgery in patients with negative imaging and sporadic zollinger ellison syndrome.